[摘 要]：目的：通過(guò)體外檢測(cè)美寶胃腸膠囊（GIC）對(duì)胚胎小白鼠小腸器官型植塊生長(zhǎng)的作用以探索GIC修復(fù)粘膜損傷的機(jī)理。方法：體外培養(yǎng)胚胎小白鼠小腸器官型植塊，并將所有植塊分為兩組：實(shí)驗(yàn)組和對(duì)照組。結(jié)果：實(shí)驗(yàn)組的小腸器官型植塊能很好地維持存活，并有大量的單個(gè)細(xì)胞、細(xì)胞克隆以及片狀粘膜組織塊長(zhǎng)出，生長(zhǎng)的時(shí)間長(zhǎng)，生長(zhǎng)狀態(tài)好；而對(duì)照組的小腸器官型植塊均很快歸于死亡。二者差異極為顯著。結(jié)論：GIC能夠維持胚胎小白鼠小腸器官型植塊的存活，并能促進(jìn)細(xì)胞增殖，某種程度上維持組織的完整性，重新組合成粘膜組織，此結(jié)果可能與GIC激活上皮干細(xì)胞有關(guān)。

[關(guān)鍵詞]：GIC；小腸植塊；生長(zhǎng)

GIC Could Maintain Survival and Promote Cell Growth of Organ-Type Explants of Intestine of Mouse Embryo Xu rong-xiang,Wang Yan-ping,Fan Ran,etc。

Central laboratory, MEBO Global Group 100053

[Abstract]：
Objective: To research on the reparative mechanism of GIC on intestinal lesion through examining the effect of on the survival and cell growth of organ-type explants of intestinal tissue of mouse embryo.
Methods: Cultured the organ-type explants of mouse intestinal tissue in vitro, all the explants were divided into two groups: test group and control group.
Results: Explants could survive in test group. Single cells, cell clones and tissue pieces could grew out of the explants and grew long and well　in test group. Conclusion: could maintain survival of intestinal explants and promote growth of cells from intestinal explants of mouse embryo and this process may be involved in the activation of epithelial stem cells.

[Key words]： GIC; intestinal explant ;　growth

大量臨床實(shí)踐顯示，GIC可能也是通過(guò)激活粘膜上皮干細(xì)胞、促進(jìn)組織細(xì)胞生長(zhǎng)的機(jī)理實(shí)現(xiàn)對(duì)損傷粘膜修復(fù)的，為了證明這一觀點(diǎn)，我們特設(shè)計(jì)了本實(shí)驗(yàn)。

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